This will be the best Baked Spaghetti Recipe you will ever make. Why Southern? There is no Mozzarella like the traditional Italian versions. Instead, I add in layers of Monterey Jack Cheese, Cheddar Cheese, and Pepperoni. The trio combination along with my HOMEMADE meat sauce creates an incredibly wicked good, cheesy spaghetti dish. Once you have tried my Southern Baked Spaghetti Recipe once, it will be a favorite choice to make again and again!

Southern Baked Spaghetti Recipe- Spaghetti Casserole

This is the best Baked Spaghetti Recipe ever. Layers of Monterey Jack and Cheddar Cheese, Pepperoni, & homemade meat sauce creates an amazing dish.
Course Main Course
Cuisine Italian
Keyword baked spaghetti, baked spaghetti recipe
Cook Time 2 hours 20 minutes
Total Time 2 hours 20 minutes
Servings 10
Calories 686kcal
Author Katie Crenshaw- A Fork's Tale


  • 28 oz can diced tomatoes
  • 28 oz can tomato sauce
  • 1 small onion, chopped
  • 1 bell pepper, chopped
  • 2 crushed garlic cloves
  • 1/2 tsp basil
  • 1/2 tsp italian seasoning
  • 1/2 tsp oregano
  • 1/2 tsp celery salt
  • 1/2 tsp salt
  • 1 tsp pepper
  • 1 tsp brown sugar
  • 1/2 cup water
  • 2 lbs ground beef
  • 8 oz cheddar cheese, shredded
  • 8 oz monterey jack cheese, shredded
  • 8 oz sliced pepperoni
  • 12 oz box of spaghetti or angel hair pasta


  • In a large stock pot, cook tomatoes, tomato sauce, onion, bell pepper, garlic, basil, Italian seasoning, oregano, celery salt, salt, pepper, and brown sugar at medium heat and bring to a boil.
  • Cover, then reduce heat and simmer for one hour.
  • Crumble and cook ground beef.
  • Add ground beef and water to stock pot and cook an additional 20 minutes.
  • Cook pasta noodles according to directions.
  • Preheat oven to 350 degrees.
  • In large 13x9 in pan lightly cover pan with meat sauce. About a ½ cup.
  • Add ½ pasta noodles. Layer half of meat sauce.
  • Layer Monterey Jack cheese. Layer remaining pasta noodles.
  • Layer remaining meat sauce. Layer Cheddar Cheese. Cover cheese with pepperoni slices.
  • Bake in oven for 30 minutes or until cheese is melted and bubbly and pepperoni is crispy.
  • Let it rest for 5 minutes, then serve in squares.


Calories: 686kcal | Carbohydrates: 35g | Protein: 38g | Fat: 43g | Saturated Fat: 19g | Cholesterol: 132mg | Sodium: 1488mg | Potassium: 873mg | Fiber: 3g | Sugar: 7g | Vitamin A: 880IU | Vitamin C: 23.7mg | Calcium: 402mg | Iron: 4.6mg